Charles Sprung is the Director Emeritus of the General Intensive Care Unit in the Department of Anesthesiology and Critical Care Medicine at Hadassah Hebrew University Medical Center in Jerusalem, Israel where he has worked for the last 20 years. He was previously the Director of the Section of Critical Care Medicine in the Department of Medicine at the VA Medical Center and the University of Miami for 13 years.
Professor Sprung has been active in research particularly studying sepsis, septic shock and ethical issues for close to 40 years. He was a member of the ACCP/SCCM consensus conference on definitions of sepsis in 1991. He has participated in many sepsis studies including those of encephalopathy and treatments with corticosteroids, monoclonal antibodies to endotoxin and tumor necrosis factor, interleukin-1 receptor antagonist, antithrombin III, tissue factor pathway inhibitor, human activated protein C and recombinant platelet-activating factor. Professor Sprung coordinated the prospective, multicenter European trial of corticosteroids in septic shock- CORTICUS. He was the Coordinator of several multi-center studies in ethics including End of Life Decision Making and Procedures in European Intensive Care Units – ETHICUS, Systematic Study of General Ethical Principles Involved in End of Life Decisions for Patients in European Intensive Care Units – ETHICATT and Triage Decision Making for the Elderly in European Intensive Care units – ELDICUS. He has published extensively in all of these areas and has more than 300 original publications and 50 books or book chapters.